08-07-2016, 11:08 PM
WinToUSB need to change the registry key, maybe the registry protection of your anti-virus software is being enabled and the anti-virus software might think change the registry key is a dangerous operation. Please temporarily deactivate your anti-virus software and try again.
By the way, VHD-based/VHDX-based Windows To Go has best compatibility when using non-certified drives to create Windows To Go workspace. And Windows Vista doesn't support VHD, so you can't create a VHD-based Windows To Go on Windows Vista. We recommend that you create the Windows To Go Workspace on a Windows 7 or later Windows OS, then you can create a VHD-based Windows To Go.
By the way, VHD-based/VHDX-based Windows To Go has best compatibility when using non-certified drives to create Windows To Go workspace. And Windows Vista doesn't support VHD, so you can't create a VHD-based Windows To Go on Windows Vista. We recommend that you create the Windows To Go Workspace on a Windows 7 or later Windows OS, then you can create a VHD-based Windows To Go.